SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model

By Bina Lee et al.

Source Cell

Highlights

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SARS-CoV-2 infection via the nasal cavity spreads to the brain
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Deterioration of Parkinson’s disease molecular and cellular phenotype by SARS-CoV-2
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SARS-CoV-2 worsens α-synuclein preformed-fibril-induced dopaminergic neuron death
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SARS-CoV-2 triggers prolonged neuroinflammation for over 60 days in hACE2-Tg mice