SARS‑CoV‑2 variants divergently infect and damage cardiomyocytes in vitro and in vivo

by admin | Aug 2, 2024 | Scientific reports, Virology, Pathophysiology

By Bobo Wing-Yee Mok et al.

Source BMC

Abstract

Background

COVID-19 can cause cardiac complications and the latter are associated with poor prognosis and increased mortality. SARS-CoV-2 variants differ in their infectivity and pathogenicity, but how they affect cardiomyocytes (CMs) is unclear.

Methods

The effects of SARS-CoV-2 variants were investigated using human induced pluripotent stem cell-derived (hiPSC-) CMs in vitro and Golden Syrian hamsters in vivo.