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Relationship between acute SARS-CoV-2 viral clearance with Long COVID Symptoms: a cohort study

by | Jul 5, 2024 | Evidence-Based Research in Western Medicine Clinical Practice, Scientific reports, Virology, Pathophysiology

By Carly Herbert et al.

Source MedRxiv

Introduction The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown.

Methods A total of 7361 asymptomatic community-dwelling people enrolled in the Test Us at Home parent study between October 2021 and February 2022. Participants self-collected anterior nasal swabs for SARS-CoV-2 RT-PCR testing every 24-48 hours for 10-14 days, regardless of symptom or infection status. Participants who had no history of COVID-19 at enrollment and who were subsequently found to have ≥1 positive SARS-CoV-2 RT-PCR test during the parent study were recontacted in August 2023 and asked whether they had experienced long COVID, defined as the development of new symptoms lasting 3 months or longer following SARS-CoV-2 infection.

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