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Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain

by | Oct 14, 2024 | Brain, Brain, Evidence-Based Research in Western Medicine Clinical Practice, Scientific reports, Virology, Pathophysiology

By Cordelia Dunai et al.

Source Frontiers

心臟感染,遙感腦炎

Latest findings suggest that a primarily pulmonary inflammatory process is rapidly associated with parainfectious immune activation in the brain and the signature of an NK cell and/or T cell response which indicates a cascade of inflammation.

Studies of brain organoids have reported that Iba1+ microglia engulf post-synaptic material contributing to synapse elimination.

From previous studies, the virus was present at low amounts in the brain and was found predominantly in the vasculature.

Clinical studies showed higher plasma levels of CCL11 in the patients who had brain fog.

Hamster studies have showed that COVID-19 leads to IL-1β and IL-6 expression within the hippocampus and medulla oblongata and is associated with decreased neurogenesis in the hippocampal dentate gyrus which leads to learning and memory deficits.

This has also been shown in direct in vitro assays—with application of serum from COVID-19 patients with delirium with elevated IL-6 leading to decreased proliferation and increased apoptosis of a human hippocampal progenitor cell line.

 

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