By Seunghoon Lee et al.
Soure:jamanetwork
Question Are plasma leptin levels associated with baseline and longitudinal changes of the 2 key protein pathologies of Alzheimer disease (AD), amyloid-beta (Aβ) and tau deposition, as measured by positron emission tomography among cognitively normal older adults?
Findings In this cohort study of 208 cognitively normal older adults, lower plasma leptin levels had a significant cross-sectional association with greater brain Aβ deposition and a significant longitudinal association with greater increase of brain tau deposition over 2 years.
Read more https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818244