By et al.
Source Cell
COVID-19 has the potential to cause damage to the cardiovascular system through excessive inflammation and cytokine storm.
SARS-CoV-2 may induce cardiovascular damage by stabilizing NFKBIZ, a kind of mRNA targets, to inhibit host cells and promote the production of more cytokines such as IL 6 and IL 8.
COVID-19 could infect and replicate in macrophages and foam cells in the coronary vessels of patients, triggering excessive inflammatory response by inhibiting the levels of type I interferon and maintaining the long-term infection status of SARS-CoV-2.
Even more, severe COVID-19 infection can cause persistent changes in the innate immune phenotype and epigenetic program of hematopoietic stem cells and progenitor cells.
These changes can cause organ dysfunction and inflammation, which can be inherited by subsequent cells.
An imaging report on multiple organs in patients with COVID-19 infection revealed that after 5 months of infection, over 30 % of patients had more than one organ abnormality.
After 6 months of infection, over 60 % of patients had multi-organ function damage, with the most severe injuries occurring in the head and lungs.
“Long-term COVID-19” is not caused by serious defects in one organ, but rather is a common result of multiple system abnormalities.
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