The interconnections between humans, animals, and the environment are often referred to as the “One Health” concept. These connections are complex and closely intertwined. During the last two decades, cat population has expanded rapidly worldwide including China. There are approximately 65 million cats in China, indicating that cats have become one of the most popular pets. This proliferation of domestic cats can lead to more human–cat interactions and heightens the risk of pathogen transmission. The intimacy of the relationships as many cat owners sleep with their cats, cuddle with them, and sometimes share food, increases the potential for disease transmission.