By Cole Maguire et al.
Source biorxiv
潛伏病源被激活，長新冠免疫大戰
The study examined over 1,000 hospitalized COVID-19 patients and found that many had reactivation of viruses they were already carrying, like Epstein-Barr virus and cytomegalovirus.
These reactivated viruses were linked to more severe COVID-19 symptoms and worse outcomes, including higher risk of death.
The researchers also saw that the reactivated viruses triggered specific immune responses, like increased inflammation and changes in gene activity.
Importantly, one virus called Anelloviridae was associated with ongoing physical symptoms in COVID-19 survivors, such as fatigue and disability.
These findings demonstrate the complex interplay between COVID-19, other viral infections, and the immune system.
They suggest that monitoring for viral reactivation could help manage both acute COVID-19 and the long-term effects, known as “long COVID.” The data provide potential new biomarkers that may guide treatment approaches for these patients.
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