SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model

對不起，此内容只適用於English。

By Bina Lee et al.

Source Cell

Highlights

•
SARS-CoV-2 infection via the nasal cavity spreads to the brain
•
Deterioration of Parkinson’s disease molecular and cellular phenotype by SARS-CoV-2
•
SARS-CoV-2 worsens α-synuclein preformed-fibril-induced dopaminergic neuron death
•
SARS-CoV-2 triggers prolonged neuroinflammation for over 60 days in hACE2-Tg mice