The kinetics of SARS-CoV-2 infection based on a human challenge study

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By Sarafa A. Iyaniwura et al.

Source PNAS

份子戰爭，適者生存

Key study used a SARS-CoV-2 human challenge dataset to model viral dynamics and immune responses.

▶️ It found that infectious virus increases sublinearly with total virus, suggesting the fraction of infectious particles declines.

▶️ Viral replication is extremely rapid, doubling every 2-3 hours early on.

▶️ Innate immunity limits viral growth initially, but wanes as infection is controlled.

▶️ Adaptive immunity, including antibodies and T cells, kicks in around 7-10 days and contributes to stepwise viral decline, though rebounds can occur as the innate response fades.

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