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How long COVID could lift the fog on neurocognitive disorders

by | Oct 3, 2024 | Long Covid19

By Michael J. Peluso and E. Wesley Ely

Source Nature

Neurocognitive symptoms, including an impaired ability to process and memorize information, are among the most common and debilitating mani-festations of long COVID, a disease experienced by as many as 400 million people worldwide, by one recent estimate (Z. Al-Aly et al. Nature Med. 30, 2148–2164; 2024). These symptoms, which can develop alongside those resulting from diseases of the lungs, heart and other organs, affect patients’ everyday functioning for months or even years following COVID-19. Matthew Fitzgerald, a 28-year-old former engineer at Tesla, described his long-COVID-related impairment during a clinic visit: “I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.”

Extreme cases of long COVID stand out — authors who cannot write; nurses who fear making a medical error — but symptoms for most people are more insidious. Many long-COVID patients have neurological problems that meet the criteria for what would normally be considered age-related mild cognitive impairment, or mild to moderate dementia.

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