By Sa´ nchez-Osuna et al.
Source iScience
INTRODUCTION
Bacteremia is a life-threatening condition with high morbidity and mortality rates that can elicit a systemic host response known as sepsis.1
These episodes often result in complicated bacteremia, usually defined by the presence of attributable mortality, the development of hematogenous
embolisms (i.e., endocarditis, discitis, and osteomyelitis of systemic abscesses), or the persistence of viable bacteria in blood
after three or more days after proper antibiotic treatment.2 Staphylococcus aureus is among the top species causing bacteremia-associated
mortality3 and persistent bacteremia,4 which in turn is linked to a higher risk of metastatic spread.5 There is increasing awareness that
patients who survive sepsis often have long-term physical, psychological, and cognitive disabilities with significant health care and social
implications.6
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