By Lindsay S. McAlpine et al.
ABSTRACT (300/300)
Background: Neuropsychiatric symptoms are prominent and can have a substantial functional impact in many
people with Long COVID (LC). The underlying pathophysiology of neuropsychiatric LC (N-LC) is unknown.
Methods: 28 individuals with acute COVID-19 (AC), 50 N-LC (new or worsening neuropsychiatric symptoms >3
months after COVID-19), and 29 post-COVID-19 controls with no LC (>3 months prior) were enrolled.
Participants underwent cross-sectional blood testing, and the N-LC and control groups underwent
neuropsychiatric testing, including verbal learning and memory, fluency, processing speed, and mental health
assessments. Fourteen soluble biomarkers of vascular health were measured in plasma. ANCOVA testing with
a Benjamini-Hochberg procedure was used to compare biomarkers between groups adjusting for co-morbidities
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