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Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors

by | Jan 2, 2025 | Scientific reports, Virology, Pathophysiology

By Jérémy Dufloo et al.

Source Nature

多源瘟疫,方興未艾

Why are we experiencing a PROLONGED “POLYPANDEMIC” CRISIS ?

Latest study identifies key animal viruses that may pose zoonotic risks to humans. It emphasizes that viruses with broad human cell tropism, particularly those from non-human mammals like bats and rodents, show potential for cross-species transmission.

Over 70% of receptor-binding proteins (RBPs) tested came from these non-human sources. Additionally, emerging viruses such as Sinu virus and Wellfleet Bay virus can enter human cells, indicating the need for monitoring.

Coronaviruses generally have strong barriers, but those like SARS-CoV-2 could pose pandemic risks if they evolve. Overall, systematic screening of animal viruses is crucial for understanding zoonotic potential.

How Animal Viruses Threaten Human Health and Why We Must Protect Ourselves from Zoonotic Infections ?

Read more click here