By Guillermo Rodriguez-Nava et al.
Source Wiley
1 INTRODUCTION
Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID, is a complex medical condition that persists in selected patients after a SARS-CoV-2 infection.1 Although the definition of PASC is still evolving, the Centers for Disease Control and Prevention (CDC) defines it as the presence of persistent symptoms beyond 28 days, while the World Health Organization and the UK Government’s Office for National Statistics consider symptoms lasting for 12 weeks or longer.2-4 This condition is characterized by over 200 associated symptoms, including hair loss, fever, fatigue, post-exertional malaise, cognitive difficulties, mood disorders, sleep disturbances, headaches, palpitations, chest pain, and shortness of breath.1, 5 PASC symptoms can vary from mild to severe, significantly impacting daily activities and work obligations. Severe symptoms usually peak within the first 28 days post-infection, while mild to moderate symptoms can persist for weeks afterward.6
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