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Fat in the Belly Correlates With Brain Amyloid

by | Dec 2, 2024 | Brain, Brain, Mental, Dementia, Parkinson's disease

By Ed Susman

Higher levels of visceral fat were correlated with more amyloid plaque in the brains of cognitively normal individuals, according to a study that hints as to why individuals with obesity are more prone to dementia.

Amyloid levels were higher among individuals with obesity compared to those without obesity (P=0.008), and were significantly associated with visceral adipose tissue (P<0.0001), found researchers led by Mahsa Dolatshahi, MD, of Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis.

Higher levels of visceral fat were related to increased amyloid, accounting for 77% of the effect of high body mass index (BMI) on amyloid accumulation, Dolatshahi reported at the annual meeting of the Radiological Society of North Americaopens in a new tab or window. Other types of fat did not explain obesity-related increased Alzheimer’s pathology.

Read more https://www.medpagetoday.com/meetingcoverage/rsna/113176