By Takashi Tanikawa et al.
Source MDPI
日本納豆，抗毒佳音
Natto extract has
been reported to inhibit SARS-CoV-2 infection in Vero E6 cells via RBD degradation. Researchers demonstrated that S protein degradation by nattokinase was blocked by heat or protein-inhibitor treatments. Our data suggest that the protease activity of nattokinase plays a
crucial role in S protein degradation. Taken together, these findings support the notion that the inhibition of SARS-CoV-2 infection by natto extract was due to S protein degradation by nattokinase. Thus, our data indicated that nattokinase and natto extracts have potential effects on the inhibition of SARS-CoV-2 host cell entry via S protein degradation.
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