Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteins
By Francesca R. Hills et al. Source: sciencedirect The SARS-CoV-2 spike protein tends to adopt an "open" shape that is more primed for binding and...
Virology, Pathophysiology
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors
By Jérémy Dufloo et al. Source Nature 多源瘟疫，方興未艾 Why are we experiencing a PROLONGED "POLYPANDEMIC" CRISIS ? Latest study identifies key animal...
H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication
By Yuncong Yin et al. Source PLOS Abstract During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a...
Oseltamivir resistance mutation N294S in human influenza A(H5N1) virus in Egypt
歷史重覆，禽流抗藥 WHO recommends using Tamiflu (oseltamivir) at 75 mg twice daily to treat A(H5N1) infections and supports stockpiling in advance of a...
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants
By Zunlong Ke et al. Source embopress 新冠大家庭，演化從未停 抗疫衰無知，死因皆不明 Evolution of SARS-CoV-2 variants has led to structural changes in Spike...
Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles
By Xu Zheng et al. Source biorxiv Latest findings suggest that understanding how the immune system, particularly cytokines, can inhibit viral...
Impact of SARS-CoV-2 Variants on COVID-19 Symptomatology and Severity during five waves.
By Bruno Belmonte Martinelli Gomes et al. Source Cell Impact of SARSCoV2 Variants on COVID19 Symptomatology and Severity during five waves :...
Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing Antibodies
By Colby T. Ford et al. Source biorxiv Researchers used computer simulations to comprehend how the H5N1 influenza virus is changing over time. The...
The kinetics of SARS-CoV-2 infection based on a human challenge study
By Sarafa A. Iyaniwura et al. Source PNAS 份子戰爭，適者生存 Key study used a SARS-CoV-2 human challenge dataset to model viral dynamics and immune...
BALB/c mice challenged with SARS-CoV-2 B.1.351 β variant cause pathophysiological and neurological changes within the lungs and brains
By Panatda Saenkham- Huntsinger et al. Source microbiologyresearch β-variant of SARS-CoV-2 primarily infected the lungs, causing tissue damage,...