By Judy George
Source Medpagetoday
A definition of Alzheimer’s disease — one that requires objective cognitive deficits in addition to brain amyloid for Alzheimer’s to be diagnosed — was proposed by the International Working Group (IWG).
The proposal was presented at the Clinical Trials on Alzheimer’s Diseaseopens in a new tab or window (CTAD) annual meeting in Madrid and published simultaneously in JAMA Neurologyopens in a new tab or window.
It’s an extension of earlier positionsopens in a new tab or window by the IWG that for clinical use, cognitive symptoms must be present and a definition of Alzheimer’s rooted only in biomarkers is not enough.
“Alzheimer’s disease should be defined as a clinical-biological entity where a diagnosis is made in consideration of a clinical disorder supported by positive amyloid and tau biomarkers,” said Howard Feldman, MD, of the University of California San Diego in La Jolla, who presented the IWG recommendations at CTAD.
This definition allows Alzheimer’s to be diagnosed at an early prodromal stage once mild but definite clinical features are evident, he noted.
Read more https://www.medpagetoday.com/meetingcoverage/ctad/112748