by Judy George
Source Medpagetoday
Key Takeaways
- Plasma leptin levels were linked with Alzheimer’s disease PET pathology in cognitively unimpaired older adults in Korea.
- Lower baseline leptin was associated with a greater increase in tau over 2 years, while leptin and beta-amyloid showed a cross-sectional association.
- While mechanistic pathways are unknown, leptin may be protective against Alzheimer’s pathology, the researchers suggested.
Plasma leptin levels were linked with Alzheimer’s disease PET pathology in cognitively unimpaired older adults, a longitudinal cohort study in Korea showed.
Over 2 years, lower baseline plasma leptin was associated with a greater increase in regional tau (β = −0.06, 95% CI −0.11 to −0.01, P=0.03), reported Dong Young Lee, MD, PhD, of the Seoul National University College of Medicine.
Read more https://www.medpagetoday.com/neurology/alzheimersdisease/109964