By et al.
Source: sciencedirect
The SARS-CoV-2 spike protein tends to adopt an “open” shape that is more primed for binding and entering human cells. In contrast, the spikes of animal coronaviruses are often in a “closed” shape, which is better for infecting their natural bat hosts but less efficient for human infection.
This structural difference is a key reason why SARS-CoV-2 was able to spread so effectively in the human population, causing a global pandemic.
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