By Jennifer Henderson
Source Medpagetoday
For children with a history of recurrent urinary tract infection (RUTI), the antibiotic nitrofurantoin and cranberry products appeared to decrease the incidence of symptomatic episodes, a meta-analysis suggested.
Across 23 randomized controlled trials involving 3,335 participants, nitrofurantoin took top place in significantly lowering odds of symptomatic UTI episodes during prophylaxis, whether compared with controls (OR 0.21, 95% CI 0.07-0.65, P=0.007) or compared with either trimethoprim or sulfamethoxazole antibiotics (OR 0.29, 95% CI 0.10-0.82, P=0.02) or trimethoprim alone (OR 0.23, 95% CI 0.08-0.66, P<0.01).
However, prophylaxis with cranberry juice or tablets also yielded 59% lower odds of symptomatic UTI episodes compared with controls (OR 0.41, 95% CI 0.23-0.74, P=0.003), reported Nikolaos Gkiourtzis, MD, MSc, of Aristotle University of Thessaloniki in Greece, and colleagues writing in Pediatricsopens in a new tab or window.
Read more https://www.medpagetoday.com/pediatrics/generalpediatrics/112733