By Panatda Saenkham- Huntsinger et al.
Source microbiologyresearch
β-variant of SARS-CoV-2 primarily infected the lungs, causing tissue damage, profound inflammatory responses, altered respiratory functions and transient but significant hypoxia.
Viral RNAs were detected across many anatomical regions of the brains in most challenged mice and triggered activation of genes encoding for NF-kB, IL-6, IP-10 and RANTES and microglial cells..
the markedly elevated level of IL-6 expression together with a high number of TRM T cells in the infected mouse brain was observed at 28 dpi following the initial infection.
Sustained IL-6 induction and brain TRM T cells after infection could alter the neurological functions, leading to the development of long-term neurological disorders.
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