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Why does severe acute respiratory syndrome coronavirus 2 attack the aged more severely?

by | Jul 19, 2024 | Scientific reports, Virology, Pathophysiology

Source JIM

In the July 2020 issue of the Journal of Inter- nal Medicine, Wu et al. conducted a retrospective study including 280 confirmed cases of COVID- 19 at the early stage of the pandemic. They found that comorbidity, early antiviral treatment, and age were three major risk factors resulting in the poor prognosis of COVID-19 patients [1]. Although the benefits of addressing comorbidity and early antivi- ral treatment are clear, the impact of age is more complex. The clinical trial indicated that people older than 65 years have a higher risk of progress- ing to severe disease. However, there is a discrep- ancy in children’s low mortality despite their imma- ture immune systems being as weak as those of older adults [2].

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